Inverse Association of Serum Leptin with Serum C-reactive protein (CRP) in Regular Hemodialysis Patients

Received:October 3, 2005 Accepted:December 20, 2005 ABSTRACT Objective: To elucidate whether and how in patients with uremia on hemodialysis the level of CRP as the marker of inflammation correlate with serum leptin. Patients and Methods: Serum leptin and CRP were determined on patients with ESRD on hemodialysis Results: The total patients were 36 (f =15, m=21). The mean patient's age were 46 (±16) years. The median length of the time patients had received hemodialysis was 19 months. The mean serum CRP was 8.7±6.6 mg/L. The mean serum leptin was 9.4±14 ng/ml. Conclusion: We found a significant inverse correlation of serum leptin with serum CRP (r= -0.57, p = 0.041). Our data supports the hypothesis that in patients on hemodialysis, the association of leptin with CRP levels was inverse which could show the positive effects of leptin on nutrition and support the theory of protective effects (reverse epidemiology) of leptin in hemodialysis patients.(Rawal Med J 2006;31:10-13)